Liver Aspartate Transaminase Isoenzymes as Biomarkers of Chronic Exposure to Chromium(VI)

Liver aspartate transaminase isoenzymes as biomarkers of chronic exposure to chromium(VI).

Exposure to hexavalent chromium compounds is associated with the risk of lung cancer, dermatitis, gastrointestinal ulcers, and other tissue damages. The aim of this study was to compare liver isoenzyme and total serum activities of aspartate aminotransferase (AST) as cytotoxic biomarkers of acute and chronic cytotoxicity of Cr(VI). We investigated the extent of cell damage caused by chromium(VI...

Evidence of phenylalanine transaminase activity in the isoenzymes of aspartate transaminase.

The transamination by pig mitochondrial and supernatant aspartate transaminase of aromatic amino acids was studied in order to determine if an analogy exists between these enzymes and a previously reported brain phenylalanine transaminase (GEORGE, H., AND GABAY, S. (1968) Biochim. Biophys. Ada, 167, 555). Supernatant and mitochondrial aspartate transaminase from pig heart can utilize aromatic a...

aspartate transaminase to platelet ratio index (apri) to assess liver fibrosis in patients with chronic liver disease

Aspartate transaminase to platelet ratio index (APRI) to assess liver fibrosis in patients with chronic liver disease

In patients with chronic liver disease (CLD), liver biopsy is currently an indispensable reference method to assess inflammatory activity and fibrosis stage and thus to estimate prognosis and guide management decisions in such patients. Given that the presence of advanced fibrosis is a predictor of nonresponse, the decision (1) to begin antiviral therapy in cases of chronic viral hepatitis is h...

noninvasive assessment of liver fibrosis with the aspartate transaminase to platelet ratio index (apri): usefulness in patients with chronic liver disease